What does the word secretagogue mean?Asked by: Celestino Friesen
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: a substance stimulating secretion (as by the stomach or pancreas)View full answer
Beside the above, Is insulin a secretagogue?
Insulin secretagogues are one type of medicine for type 2 diabetes. Many people with type 2 diabetes don't make enough insulin. Insulin secretagogues help your pancreas make and release (or secrete) insulin. Insulin helps keep your blood glucose from being too high.
Also to know, Which one of the following is a secretagogue?. Secretagogues, such as sulfonylureas and glinides, increase insulin secretion from the pancreas. Secretagogues are medicines that stimulate the beta cell to secrete insulin. Secretagogues include the sulfonylureas and glinides.
In this manner, What is the meaning of sensitizer?
A sensitizer is defined by OSHA as "a chemical that causes a substantial proportion of exposed people or animals to develop an allergic reaction in normal tissue after repeated exposure to the chemical." ... The condition of being sensitized to a chemical is called chemical hypersensitivity.
Which is an example of sensitizer?
Examples of sensitizers include diazomethane, chromium, nickel, formaldehyde, isocyanates, arylhydrazines, benzylic and allylic halides, and many phenol derivatives. Sensitizer exposure can lead to all of the symptoms associated with allergic reactions, or can increase an individual's existing allergies.
A hepatotoxin is a toxic chemical substance that can cause damage to or otherwise injure the liver.
Sulfonylureas stimulate insulin secretion from the pancreas; because of this, they are sometimes referred to as “insulin secretagogues.” Over time, such therapy fails, and additional treatment is required.
Metformin and thiazolidinediones (TZDs) are used for the treatment of type 2 diabetes. As both drugs ameliorate hyperglycemia by improving glucose metabolism of target tissues of insulin, they are particularly prescribed to patients with severe insulin resistance.
Metformin is the only biguanide currently available in most countries for treating diabetest. Glucophage (metformin) and Glucophage XR (metformin extended-release) are well-known brand names for these drugs. Others include Fortamet, Glumetza, and Riomet.
To date, few long-term, rigorously controlled studies have examined the efficacy and safety of GHSs, although GHSs might improve growth velocity in children, stimulate appetite, improve lean mass in wasting states and in obese individuals, decrease bone turnover, increase fat-free mass, and improve sleep.
Medical Definition of secretagogue
: a substance that stimulates secretion (as by the stomach or pancreas)
People with type 2 diabetes can often manage their condition without insulin therapy. Alternative treatment options include lifestyle and dietary changes and non-insulin medications, such as metformin.
Metformin is usually the first choice of most doctors, assuming that the woman is a candidate for taking the medication. It works by increasing the cell's sensitivity to insulin and also suppresses the production of glucose by the liver.
Sulfonylureas are a group of medicines used in the management of Type 2 diabetes. Sulfonylureas lower blood glucose levels by stimulating insulin release from the Beta cells of the pancreas.
Thiazolidinediones are therefore contraindicated in patients with moderate to severe symptoms or signs of angina or heart failure during daily activities or at rest (New York Heart Association (NYHA) class III or IV cardiac functional status).
Pioglitazone belongs to a class of drugs known as thiazolidinediones or "glitazones". Metformin and pioglitazone work by helping to restore your body's proper response to the insulin you naturally produce.
TZDs work by targeting the PPAR-gamma receptor, which activates a number of genes in the body and plays an important role in how the body metabolises glucose and how the body stores fat.
Insulin production, secretion
Insulin is produced in the pancreas and is synthesized in the pancreas within the beta cells of the islets of Langerhans.
As an insulin sensitizer, metformin takes pleiotropic actions and exerts protective effects on multiple organs mainly in insulin-targeted tissues such as liver, muscle, and adipose tissues.
- Skin and eyes that appear yellowish (jaundice)
- Abdominal pain and swelling.
- Swelling in the legs and ankles.
- Itchy skin.
- Dark urine color.
- Pale stool color.
- Chronic fatigue.
- Nausea or vomiting.
Too much refined sugar and high-fructose corn syrup causes a fatty buildup that can lead to liver disease. Some studies show that sugar can be as damaging to the liver as alcohol, even if you're not overweight. It's one more reason to limit foods with added sugars, such as soda, pastries, and candy.
The liver is very resilient and capable of regenerating itself. Each time your liver filters alcohol, some of the liver cells die. The liver can develop new cells, but prolonged alcohol misuse (drinking too much) over many years can reduce its ability to regenerate.