Is podophyllotoxin safe during pregnancy?Asked by: Nikki O'Conner V
Score: 5/5 (21 votes)
Although local podophyllotoxin is part of the first-line treatment for anogenital warts, it is currently contraindicated during pregnancy5,9 because of its antimitotic properties, which have embryotoxic effects in other drugs. However, data on podophyllotoxin use during pregnancy are limited.View full answer
Subsequently, question is, Is Podophyllin safe in pregnancy?
Pregnancy: There have been reports of complications associated with the topical use of podophyllin on condylomata of pregnant patients including birth defects, fetal death and stillbirth(6). In the absence of controlled safety studies, podophyllin remains contraindicated for use on pregnant patients.
Herein, Is imiquimod safe during pregnancy?. However, the use of Imiquimod in pregnancy is not recommended and the US FDA classified Imiquimod as a Category B drug, with its use indicated only as a last resort when the benefits are thought to outweigh the risks.
Moreover, Is Warticon safe for pregnancy?
Warticon Cream is not recommended during pregnancy or in women of childbearing potential not using contraception. There is insufficient information on the excretion of topically applied podophyllotoxin in human milk. A risk to the newborns/infants cannot be excluded.
What is podophyllotoxin used for?
Podophyllotoxin is a non- alkaloid extract, of the Podophyllum species. It is used on the skin as a topical treatment of external genital warts, caused by some types of the human papillomavirus (HPV), and other warts.
LOW CLINICAL TOXICITY
In contrast with podophyllin, topical use of 0.15%–0.5% podophyllotoxin preparations are very safe for clinical use.
Of patient-applied topical treatments, podophyllotoxin 0.5% solution was found to be the most effective at achieving complete clearance, and was associated with a statistically significant difference compared with imiquimod 5% cream and polyphenon E 10% ointment (p<0.05).
Having genital warts shouldn't affect your delivery. Sometimes, large warts may cause bleeding during delivery. Rarely, genital warts can grow large enough during pregnancy to block the birth canal or make childbirth more difficult. If this happens, your doctor will likely recommend having a cesarean delivery.
If you are pregnant and you have warts, your GP may consider treatment using duct tape, cryotherapy or salicylic acid. Salicylic acid may be used to treat warts during pregnancy, as long as it is used on a small area for a limited period of time.
It's not likely. Women who have or have had HPV — the human papilloma virus — have successful pregnancies and their babies are not harmed by their HPV infections. HPV is a very common sexually transmitted infection that affects millions of women and men around the world.
Using too much imiquimod topical or using it for too long can increase your risk of severe skin reactions. Do not use two different forms of imiquimod topical on the same treatment area. Read and carefully follow any Instructions for Use provided with your medicine.
Imiquimod is in a class of medications called immune response modifiers. It treats genital and anal warts by increasing the activity of the body's immune system. It is not known exactly how imiquimod cream works to treat actinic keratoses or superficial basal cell carcinoma.
Basal cell skin cancer (BCC)
Imiquimod cream is approved in the UK for the treatment of superficial basal cell skin cancers measuring up to 2cm across. It can be used on your chest, neck, arms or legs (including hands and feet). It is not approved for a type of BCC called nodular BCC.
Common side effects of Podocon-25 include:
- mild bloating,
- application site reactions (slight stinging, pain, numbness, tingling, or burning),
- fever, and.
- intestinal obstruction.
Adults and children—Apply to the affected area(s) of the skin and leave on the skin for one to six hours. Treatment may be repeated every week for up to six weeks.
It works by destroying the tissue of the growth. A few hours after podophyllum is applied to a wart, the wart becomes blanched (loses all color). In 24 to 48 hours, the medicine causes death of the tissue. After about 72 hours, the wart begins to slough or come off and gradually disappears.
Genital warts are a sexually transmitted infection (STI). They typically appear as fleshy growths in the tissues of the genitals of both men and women, though many people never experience any symptoms. Genital warts are caused by certain strains of the human papillomavirus (HPV).
Genital warts have been shown to grow faster during pregnancy due to discharge, as well as changes to in hormones and immune system. But genital warts during pregnancy are not generally considered to pose a serious risk to you or your baby.
Cryotherapy: This method may also be used during pregnancy and involves freezing the wart with liquid nitrogen. Multiple sessions may be needed to remove the wart. Injection of medication: Your doctor may inject medication into the wart to treat the virus.
HPV is not transmitted through bodily fluids such as semen or saliva, but through skin-to-skin contact. This happens most easily through sexual contact, such as vaginal, anal and oral sex.
According to the Institute of Medicine, pregnant women need to drink ten 8-ounce glasses of water per day. When you're breastfeeding, that daily intake should increase to thirteen 8-ounce glasses per day. Most people are familiar with the 8×8 rule for daily water intake: eight 8-ounce glasses of water per day.
Cervix: HPV and cancer symptoms
- pain during sex.
- pain in the pelvic region.
- unusual discharge from the vagina.
- unusual bleeding, such as after sex.
The liquid is applied twice a day on each spot. The spots should eventually become inflamed, before healing and disappearing within the next few weeks. You should stop using the medicine once the spots have started to become inflamed, or after 14 days if the medicine does not seem to be working.
One cannot just buy podofilox online or get podofilox OTC in the United States from a pharmacy as it is a medication that requires a prescription before it can be dispensed. Because of this restriction, the first step to getting a podofilox cream prescription is consulting a licensed medical provider.
Most HPV infections in young men and women are transient, lasting no more than one or two years. Usually, the body clears the infection on its own. It is estimated that the infection will persist in only about 1% of women. It is those infections that persist which may lead to cancer.